St. Vital lies in the southeast quadrant of Winnipeg, along the east shore of the Red River. It is bounded to the east by the Seine River, which it follows until it hits the south Perimeter Hwy. South of the Perimeter Hwy, it includes a large area, meeting the borders of the municipalities of Ritchot and Springfield. The main east-west thoroughfares are Fermor Ave (Route 135), Bishop Grandin Blvd (Route 165), and the south Perimeter Hwy. The main north-south thoroughfares are Dunkirk Dr (Route 62), St Mary's Rd, Dakota St, and St Anne's Rd (Route 150).